Wed, 27 September 2017
This week welcome to the show Dr. Dale Bredesen. Dr. Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO.
The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explains the erosion of memory seen in Alzheimer’s disease, and has opened the door to a new therapeutic approach. He has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost. This model is contrary to popular dogma that Alzheimer’s is a disease of toxicity, caused by the accumulation of sticky plaques in the brain. Bredesen believes the amyloid beta peptide, the source of the plaques, has a normal function in the brain — promoting signals that allow some of the nerve connections to lapse. Thus the increase in the peptide that occurs in Alzheimer’s disease shifts the memory-making vs. memory-breaking balance in favor of memory loss. This work has led to the identification of several new therapeutic candidates that are currently in pre-clinical trials.
Dr. Bredesen’s novel insights into the fundamental nature of Alzheimer’s disease recently attracted an investment of $3.5 million toward a $10 million goal for initial clinical trials of these new therapeutics. This generous support came from the private venture capitalist Douglas Rosenberg, who is helping to fund the Alzheimer’s Drug Discovery Network, centered at the Buck Institute. The unit is screening drug candidates to find those that can preserve a healthy balance in the signaling pathways that support memory. Dr. Bredesen’s work on nerve cell signaling is also the focus of a collaboration between the Buck Institute and BioMarin Pharmaceuticals, Inc., which is seeking treatments for a rare form of Alzheimer’s disease, early onset Familial Alzheimer’s Disease (eFAD), which may develop in people as young as 30 years of age.
Questions we ask in this episode:
Try a Free Sample of 180 Superfood Protein Blend:
We have Dr. Dale Bredesen on the show. I’ve got to just say, it never ceases to amaze me some of the information that comes out on these podcasts. I just feel like the luckiest guy alive sometimes. There’s one that myself and Stuart love today. Dale was just a champion. We get into neurodegenerative diseases today, as that’s Dale’s area of expertise. He is a internationally recognized expert in the mechanisms of neurodegenerative diseases, such as Alzheimer’s disease. [00:01:00] He’s also come out with a new book, which is a New York best seller, The End of Alzheimer’s. It was an instant New York Times success. Now the book, as well, is covering this groundbreaking plan to prevent and reverse Alzheimer’s disease. That fundamentally changes how we understand cognitive decline. But there are so many valuable lessons within this podcast for all of us, whether we know anyone with a neurodegen- … I can’t even get the words out, neurodegenerative disease, or not. [00:01:30] Yeah, just get into it. Enjoy it. There’s quite a lot of technicality in here as well, but it’s definitely worth a couple of listens. If you know anyone that is suffering from neurodegenerative diseases, then please share this podcast with them, because I think there’s definitely hope. This podcast will inspire them. It was just, yeah, phenomenal, and I’m keen to try and get this message far and wide. [00:02:00] The last thing I want to say before we go over to Dale is that if you are enjoying the shows, guys, I would love you to leave a review, five star it, and subscribe it, just to continue to help us get this word out there. I think we’re three reviews short of 100 reviews for here in Australia or anywhere. That’s fantastic. If you could be one of those three to get us over the line, that would be brilliant. Anyway, let’s go over to Dr. Dale Bredesen. This podcast is awesome. Enjoy! [00:02:30] Hi, this is Guy Lawrence. I’m joined with Stuart Cooke, as always. Good morning Stuart.
Our awesome guest today is Dr. Dale Bredesen. Dale, welcome to the show.
Thanks very much for having me.
Look, it’s fantastic, mate. We always kickoff and ask the same question to all our guests when they come on the show. That is, if a complete stranger stopped you on the street and asked you what you did for a living, what would you say?
I do everything possible to see if we can improve people who have neurodegenerative illness. [00:03:00]
Beautiful, perfect. I couldn’t say it any better. The other thing we always ask as well, Dale, is, would you mind just filling us a little bit in of your journey, your background, and what led you to be so passionate about this work, and making waves in the industry?
[00:03:30] Yeah. I came from a different place than most people who are doing this sort of medicine today. I came from a very classical science background. I was interested in mathematics and chemistry when I was a kid. I went to Caltech, and spent time at MIT as well for those reasons, working in chemistry. And then decided that if we were going to do something … I got very, very interested in the brain. When I was a freshman in college, I read a very interesting book called The Machinery of the Brain. I got very excited about that and kind of got hooked for life on neuroscience. [00:04:00] But I realized that if I was going to make any inroads into the illnesses that affect the brain, I really needed to go to medical school. So I went to medical school and got a lot of criticism for being a scientist wanting to go to medical school. But I went into neurology, and as you know, neurology has a long history of being tremendous diagnosticians. And, of course, Sherlock Holmes was actually based on a real neurologist. But in general, neurologists have been known to be the group that does not do much about the treatment side, very good with diagnosis, not so great, not so successful with treatment. And the diseases, no question, they’ve been very, very difficult.
Full Transcript & Video Version:
Sun, 17 September 2017
This week's episode was a bit of an impromptu podcast as I welcome back to the show Dave O'Brien. We are also joined by Josh Komen who share his journey with leukemia.
I was at Dave's facility in Melbourne hosting my workshop "Let It In' and thought it would be great to get these guys on the show.
Dave has been working with Josh for past 12 months and it was fantastic to hear both sides of the story. Dave with the science and the approach he's been talking with Josh; And for Josh, he shares his story, struggles and triumphs and his amazing improvements since he's been working with Dave.
Dave is co-founder of the world class facility 5th Element Wellness in Melbourne.
Brought to you by www.180nutrition.com.au
Tue, 5 September 2017
This week welcome to the show Dr. David Hamilton. David has a first class honors degree in chemistry, specializing in biological and medicinal chemistry. He has the slightly geeky honour of having achieved 100% in his 3rd year university degree exam in ‘Statistical Mechanics’, which is a branch of quantum physics applied to chemistry.
After completing his PhD, he worked for 4 years in the pharmaceutical industry, first developing drugs for cardiovascular disease and cancer, then a year managing leadership and change projects. During this time he also served as an athletics coach and manager of Sale Harriers Manchester, one of the UK’s largest athletics clubs, leading the Junior Men’s team to three successive UK finals. Upon leaving the pharmaceutical industry, he co-founded the international relief charity Spirit Aid Foundation and served as a director for 2 years.
While writing his first book (2004-2005), he taught chemistry (main) plus ecology and mathematics (secondary) at West College Scotland (formerly, James Watt College of Further and Higher Education) and tutored chemistry at the University of Glasgow.
He’s now a bestselling author of 8 books (No’s 9 and 10 are due out in 2017) published by Hay House UK, and offer talks and workshops that use science to inspire – fusing neuroscience, the mind-body connection, kindness, and philosophical and eastern spiritual teachings. He also writes a regular blog on his website as well as occasional blogs for the Huffington Post (US edition) and Psychologies Life Labs, and is a columnist for Soul and Spirit Magazine. In 2016, David won the Kindred Spirit, ‘Best MBS Writer Award’.
He has been featured in numerous publications, including ELLE, RED Magazine, Psychologies, YOU Magazine, Good Housekeeping (both UK & US), and several newspapers.
You might wonder how he got into writing on the subjects he does. In his own words, “Well, during my time in the pharmaceutical industry, I was fascinated by the placebo effect – how people improve through believing they are receiving a drug – so I began to study mind-body interactions in my spare time. I decided to leave the pharmaceutical industry after 4 years because I wanted to educate about the mind-body connection, help people to believe in themselves more, and spread a little more kindness in the world in my own way.”
Questions we ask in this episode:
We have on the show Dr David Hamilton, and I have to say I truly loved every minute of this show. Now David has a first class honors degree in chemistry, specializing in biological and medicinal chemistry. After completing his PhD he worked for four years in the pharmaceutical industry, first developing drugs for cardiovascular disease and cancer, then a year managing leadership and change projects. Now he is also a best selling author of 8 books published by Hay House in the UK, and offers talks and workshops that use science to inspire, fusing neuroscience, the mind body connection, kindness and a philosophical and eastern spiritual teaching, so yes you can see why I loved this episode so much.
[00:01:30] [00:02:00] And what I loved about David's journey, A) he is just an upbeat positive awesome dude, but from that as well we get stuck into the placebo at first and what he was seeing from back in his pharmaceutical days, and comparing that to the actual drugs people were taking, which is just fascinating, and then we get into his new book, the Side Effects of Kindness, and he talks at it from a biological and physical perspective as well of what is going on, and it was just fascinating, and yeah it was awesome, so if you want to do an act of kindness after listening to this show, feel free to leave us a review on iTunes, or actually share this episode with someone that you think might really appreciate it. Because there is a lot in here and I have no doubt you will enjoy it as well. Now you might have heard me mention on a couple of podcasts in the past, I've personally myself set up a closed Facebook group and the group is designed, if you kind of enjoy this information and this content, me personally I have a lot of interest in meditation, neuroscience and the changes that are going on within myself and my life, and it has had a huge positive impact on me over the last 3 or 4 years as I have been exploring a lot of it. [00:02:30] Anyway I have created this Facebook group called Guy Lawrence Let It In, and if this kind of stuff inspires you, you enjoy it and you want to hang out with like minded people, come on over and, yeah I will welcome you into the group and come and introduce yourself and let me know you found it on the podcast. Anyway, so I just want to mention that. It is Guy Lawrence Let It In, just do a Facebook search. Anyway lets go over to Dr David Hamilton, this episode is awesome. Hi this is Guy Lawrence, I am joined with Stuart Cook as always, good afternoon Stu.
And our awesome guest today all the way from the UK, is Dr David Hamilton. David, welcome to the show.
Oh well, thanks very much, nice to be here. [00:03:00]
It is a pleasure mate, and we ask one little question just to kick start the show to all our guests, and that is if a complete stranger stopped you on the street and asked you what you did for a living, what would you say?
I write books and I give talks. In a nutshell. I would probably tell them the kind of topic that I wrote on but it depends on how ... if we were moving fast in opposite directions. [00:03:30]
Full Transcript & Video Version: